Targeted use of Alpha Particles: Current Status in Cancer Therapeutics
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چکیده
منابع مشابه
Targeted use of Alpha Particles: Current Status in Cancer Therapeutics
Purpose of review: To summarize the current role of alpha particles in cancer treatment including both clinical and pre-clinical data. Recent findings: Though discovered more than hundred years ago, no targeted alpha emitters have yet to be approved as a systemic approach to cancer therapy. Until recently, most approaches to target alpha particle emitters utilized conjugation with antibodies th...
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Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine & Radiation Therapy
سال: 2012
ISSN: 2155-9619
DOI: 10.4172/2155-9619.1000136